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While p73 is essential, p63 is completely dispensable for the development of the central nervous system
The ancient p53 paralogs p63 and p73 regulate specific tissue formation, cell survival and cell death via their TA and ΔN isoforms. Targeted disruption of the p73 locus leads to severe defects in the development of the central nervous system (CNS), and p73 has recently been shown to be an essential...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Landes Bioscience
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174004/ https://ncbi.nlm.nih.gov/pubmed/21293190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.4.14859 |
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