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Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides

We used antisense morpholino oligonucleotides (AMOs) to redirect and restore normal splicing of three prototypic splicing mutations in the ataxia-telangiectasia mutated (ATM) gene. Two of the mutations activated cryptic 5′ or 3′ splice sites within exonic regions; the third mutation activated a down...

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Bibliographische Detailangaben
Hauptverfasser: Du, Liutao, Pollard, Julianne M., Gatti, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1832221/
https://ncbi.nlm.nih.gov/pubmed/17389389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608616104
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