Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with autoimmune-like manifestations. Whether B cells play a role in OS pathogenesis is so far unexplored. Here we report the detection of plasma cells...

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Bibliografski detalji
Glavni autori: Cassani, Barbara, Poliani, Pietro Luigi, Marrella, Veronica, Schena, Francesca, Sauer, Aisha V., Ravanini, Maria, Strina, Dario, Busse, Christian E., Regenass, Stephan, Wardemann, Hedda, Martini, Alberto, Facchetti, Fabio, van der Burg, Mirjam, Rolink, Antonius G., Vezzoni, Paolo, Grassi, Fabio, Traggiai, Elisabetta, Villa, Anna
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901059/
https://ncbi.nlm.nih.gov/pubmed/20547828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091928
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