Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with autoimmune-like manifestations. Whether B cells play a role in OS pathogenesis is so far unexplored. Here we report the detection of plasma cells...

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Main Authors: Cassani, Barbara, Poliani, Pietro Luigi, Marrella, Veronica, Schena, Francesca, Sauer, Aisha V., Ravanini, Maria, Strina, Dario, Busse, Christian E., Regenass, Stephan, Wardemann, Hedda, Martini, Alberto, Facchetti, Fabio, van der Burg, Mirjam, Rolink, Antonius G., Vezzoni, Paolo, Grassi, Fabio, Traggiai, Elisabetta, Villa, Anna
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901059/
https://ncbi.nlm.nih.gov/pubmed/20547828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091928
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