Sirolimus Therapy to Halt the Progression of ADPKD

Activation of mammalian target of rapamycin (mTOR) pathways may contribute to uncontrolled cell proliferation and secondary cyst growth in patients with autosomal dominant polycystic kidney disease (ADPKD). To assess the effects of mTOR inhibition on disease progression, we performed a randomized, c...

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Main Authors: Perico, Norberto, Antiga, Luca, Caroli, Anna, Ruggenenti, Piero, Fasolini, Giorgio, Cafaro, Mariateresa, Ondei, Patrizia, Rubis, Nadia, Diadei, Olimpia, Gherardi, Giulia, Prandini, Silvia, Panozo, Andrea, Bravo, Rodolfo Flores, Carminati, Sergio, De Leon, Felipe Rodriguez, Gaspari, Flavio, Cortinovis, Monica, Motterlini, Nicola, Ene-Iordache, Bogdan, Remuzzi, Andrea, Remuzzi, Giuseppe
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2010
主題:
Clinical Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900967/
https://ncbi.nlm.nih.gov/pubmed/20466742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009121302
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