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Protonation states of the key active site residues and structural dynamics of glmS riboswitch as reveled by molecular dynamics

The glmS catalytic riboswitch is part of the 5'-untranslated region of mRNAs encoding glucosamine-6-phosphate (GlcN6P) synthetase (glmS) in numerous Gram-positive bacteria. Binding of the cofactor GlcN6P induces site-specific self-cleavage of the RNA. However, detailed reaction mechanism as wel...

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Autori principali: Banáš, Pavel, Walter, Nils G., Šponer, Jiří, Otyepka, Michal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900856/
https://ncbi.nlm.nih.gov/pubmed/20536206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9109699
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