A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

During infection, vertebrates develop “sickness syndrome,” characterized by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and inflammation. These pathophysiological responses are mediated by cytokines, including TNF and IL-1, released during the innate immune response to inv...

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Detalhes bibliográficos
Main Authors: Yang, Huan, Hreggvidsdottir, Hulda S., Palmblad, Karin, Wang, Haichao, Ochani, Mahendar, Li, Jianhua, Lu, Ben, Chavan, Sangeeta, Rosas-Ballina, Mauricio, Al-Abed, Yousef, Akira, Shizuo, Bierhaus, Angelika, Erlandsson-Harris, Helena, Andersson, Ulf, Tracey, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900689/
https://ncbi.nlm.nih.gov/pubmed/20547845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003893107
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