PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

In order to proliferate and expand in an environment with limited nutrients, cancer cells co-opt cellular regulatory pathways that facilitate adaptation and thereby maintain tumor growth and survival potential. The endoplasmic reticulum (ER) is uniquely positioned to sense nutrient deprivation stres...

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Bibliographic Details
Main Authors: Bobrovnikova-Marjon, Ekaterina, Grigoriadou, Christina, Pytel, Dariusz, Zhang, Fang, Ye, Jiangbin, Koumenis, Constantinos, Cavener, Douglas, Diehl, J. Alan
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900533/
https://ncbi.nlm.nih.gov/pubmed/20453876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.153
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