PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with...

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Autori principali: Bobrovnikova-Marjon, Ekaterina, Pytel, Dariusz, Riese, Matthew J., Vaites, Laura Pontano, Singh, Nickpreet, Koretzky, Gary A., Witze, Eric S., Diehl, J. Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372262/
https://ncbi.nlm.nih.gov/pubmed/22493067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00063-12
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