Inhibition of Sp1 dependent transcription and antitumor activity of the new aureolic acid analogues Mithramycin SDK and SK in human ovarian cancer xenografts

OBJECTIVE: Increased activity of Sp family of transcription factors is a frequent and critical event in cancer development and progression. Genes governing tumor growth, invasion and angiogenesis are regulated by Sp factors, like Sp1, Sp3 or Sp4, and are frequently over-expressed in tumors. Targetin...

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Hlavní autoři: Previdi, Sara, Malek, Anastasia, Albertini, Veronica, Riva, Cristina, Capella, Carlo, Broggini, Massimo, Carbone, Giuseppina M., Rohr, Jurgen, Catapano, Carlo V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900446/
https://ncbi.nlm.nih.gov/pubmed/20452660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2010.03.020
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