Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers

The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of...

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Autori principali: Leng, Shuguang, Stidley, Christine A., Bernauer, Amanda M., Picchi, Maria A., Sheng, Xin, Frasco, Melissa A., Van Den Berg, David, Gilliland, Frank D., Crowell, Richard E., Belinsky, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2008
Soggetti:
Molecular Epidemiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2899849/
https://ncbi.nlm.nih.gov/pubmed/18499700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn121
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