Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers

The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of...

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Main Authors: Leng, Shuguang, Stidley, Christine A., Bernauer, Amanda M., Picchi, Maria A., Sheng, Xin, Frasco, Melissa A., Van Den Berg, David, Gilliland, Frank D., Crowell, Richard E., Belinsky, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Molecular Epidemiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2899849/
https://ncbi.nlm.nih.gov/pubmed/18499700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn121
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