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PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
The inhibitory receptor programmed death 1 (PD-1) is upregulated on antigen-specific CD8(+) T cells during persistent viral infections. Interaction with PD-1 ligand 1 (PD-L1) contributes to functional exhaustion of responding T cells and may limit immunopathology during infection. PD-L1 is expressed...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898584/ https://ncbi.nlm.nih.gov/pubmed/20551512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40040 |
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