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PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice

The inhibitory receptor programmed death 1 (PD-1) is upregulated on antigen-specific CD8(+) T cells during persistent viral infections. Interaction with PD-1 ligand 1 (PD-L1) contributes to functional exhaustion of responding T cells and may limit immunopathology during infection. PD-L1 is expressed...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mueller, Scott N., Vanguri, Vijay K., Ha, Sang-Jun, West, Erin E., Keir, Mary E., Glickman, Jonathan N., Sharpe, Arlene H., Ahmed, Rafi
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2010
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898584/
https://ncbi.nlm.nih.gov/pubmed/20551512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40040
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