Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

The TMPRSS2-ERG fusion, present in 50% of prostate cancers, is less common in prostatic intra-epithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgeni...

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Bibliografiske detaljer
Main Authors: King, Jennifer C., Xu, Jin, Wongvipat, John, Hieronymus, Haley, Carver, Brett S., Leung, David H., Taylor, Barry S., Sander, Chris, Cardiff, Robert D., Couto, Suzana S., Gerald, William L., Sawyers, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898503/
https://ncbi.nlm.nih.gov/pubmed/19396167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.371
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