High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors

Human haematopoietic prostaglandin D synthase (H-PGDS; EC 5.3.99.2) produces prostaglandin D(2), an allergic and inflammatory mediator, in mast cells and Th2 cells. H-PGDS has been crystallized with novel inhibitors with half-maximal inhibitory concentrations (IC(50)) in the low nanomolar range by t...

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Detalhes bibliográficos
Main Authors: Takahashi, Sachiko, Tsurumura, Toshiharu, Aritake, Kosuke, Furubayashi, Naoki, Sato, Masaru, Yamanaka, Mari, Hirota, Erika, Sano, Satoshi, Kobayashi, Tomoyuki, Tanaka, Tetsuo, Inaka, Koji, Tanaka, Hiroaki, Urade, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2010
Assuntos:
Crystallization Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898477/
https://ncbi.nlm.nih.gov/pubmed/20606289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110020828
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