Phosphopeptide Screen Uncovers Novel Phosphorylation Sites of Nedd4-2 That Potentiate Its Inhibition of the Epithelial Na(+) Channel

The E3 ubiquitin ligase Nedd4-2 regulates several ion transport proteins, including the epithelial Na(+) channel (ENaC). Nedd4-2 decreases apical membrane expression and activity of ENaC. Although it is subject to tight hormonal control, the mechanistic basis of Nedd4-2 regulation remains poorly und...

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Detalhes bibliográficos
Main Authors: Hallows, Kenneth R., Bhalla, Vivek, Oyster, Nicholas M., Wijngaarden, Marjolein A., Lee, Jeffrey K., Li, Hui, Chandran, Sindhu, Xia, Xiaoyu, Huang, Zhirong, Chalkley, Robert J., Burlingame, Alma L., Pearce, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898378/
https://ncbi.nlm.nih.gov/pubmed/20466724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.084731
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