β(1)Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells

Our previous work has established that the metabolic sensor AMP-activated protein kinase (AMPK) inhibits the epithelial Na(+) channel (ENaC) by promoting its binding to neural precursor cell–expressed, developmentally down-regulated 4-2, E3 ubiquitin protein ligase (Nedd4-2). Here, using MS analysis...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ho, Pei-Yin, Li, Hui, Pavlov, Tengis S., Tuerk, Roland D., Tabares, Diego, Brunisholz, René, Neumann, Dietbert, Staruschenko, Alexander, Hallows, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065188/
https://ncbi.nlm.nih.gov/pubmed/29858246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003082
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