Neural Precursor Cell-expressed Developmentally Down-regulated Protein 4-2 (Nedd4-2) Regulation by 14-3-3 Protein Binding at Canonical Serum and Glucocorticoid Kinase 1 (SGK1) Phosphorylation Sites

Regulation of epithelial Na(+) channel (ENaC)-mediated transport in the distal nephron is a critical determinant of blood pressure in humans. Aldosterone via serum and glucocorticoid kinase 1 (SGK1) stimulates ENaC by phosphorylation of the E3 ubiquitin ligase Nedd4-2, which induces interaction with...

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Detalhes bibliográficos
Main Authors: Chandran, Sindhu, Li, Hui, Dong, Wuxing, Krasinska, Karolina, Adams, Chris, Alexandrova, Ludmila, Chien, Allis, Hallows, Kenneth R., Bhalla, Vivek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199524/
https://ncbi.nlm.nih.gov/pubmed/21900244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293233
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