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Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

The epithelial sodium channel (ENaC) is an integral component of the pathway for Na(+) absorption in epithelial cells. The ubiquitin ligases Nedd4 and Nedd4-2 bind to ENaC and decrease its activity. Conversely, Serum- and Glucocorticoid regulated Kinase-1 (SGK1), a downstream mediator of aldosterone...

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Detalhes bibliográficos
Main Authors: Dominik Wiemuth, J Shaun Lott, Kevin Ly, Ying Ke, Paul Teesdale-Spittle, Peter M Snyder, Fiona J McDonald
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-08-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2921341?pdf=render
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