Interaction of Serum- and Glucocorticoid Regulated Kinase 1 (SGK1) with the WW-Domains of Nedd4-2 Is Required for Epithelial Sodium Channel Regulation

BACKGROUND: The epithelial sodium channel (ENaC) is an integral component of the pathway for Na(+) absorption in epithelial cells. The ubiquitin ligases Nedd4 and Nedd4-2 bind to ENaC and decrease its activity. Conversely, Serum- and Glucocorticoid regulated Kinase-1 (SGK1), a downstream mediator of...

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Main Authors: Wiemuth, Dominik, Lott, J. Shaun, Ly, Kevin, Ke, Ying, Teesdale-Spittle, Paul, Snyder, Peter M., McDonald, Fiona J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921341/
https://ncbi.nlm.nih.gov/pubmed/20730100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012163
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