The Serum- and Glucocorticoid-inducible Kinases SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-2 and GTPase Rab11

The hERG (human ether-a-go-go-related gene) encodes the α subunit of the rapidly activating delayed rectifier potassium channel (I(Kr)). Dysfunction of hERG channels due to mutations or certain medications causes long QT syndrome, which can lead to fatal ventricular arrhythmias or sudden death. Alth...

Full description

Saved in:
Bibliographic Details
Main Authors: Lamothe, Shawn M., Zhang, Shetuan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663528/
https://ncbi.nlm.nih.gov/pubmed/23589291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453670
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items