Cell Surface Expression of Human Ether-a-go-go-related Gene (hERG) Channels Is Regulated by Caveolin-3 Protein via the Ubiquitin Ligase Nedd4-2

The human ether-a-go-go-related gene (hERG) encodes the rapidly activating delayed rectifier potassium channel (I(Kr)) which plays an important role in cardiac repolarization. A reduction or increase in hERG current can cause long or short QT syndrome, respectively, leading to fatal cardiac arrhythm...

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Hlavní autoři: Guo, Jun, Wang, Tingzhong, Li, Xian, Shallow, Heidi, Yang, Tonghua, Li, Wentao, Xu, Jianmin, Fridman, Michael D., Yang, Xiaolong, Zhang, Shetuan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460420/
https://ncbi.nlm.nih.gov/pubmed/22879586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389643
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