The Role of Monoubiquitination in Endocytic Degradation of Human Ether-a-go-go-related Gene (hERG) Channels under Low K(+) Conditions

A reduction in extracellular K(+) concentration ([K(+)](o)) causes cardiac arrhythmias and triggers internalization of the cardiac rapidly activating delayed rectifier potassium channel (I(Kr)) encoded by the human ether-a-go-go-related gene (hERG). We investigated the role of ubiquitin (Ub) in endo...

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Detalhes bibliográficos
Main Authors: Sun, Tao, Guo, Jun, Shallow, Heidi, Yang, Tonghua, Xu, Jianmin, Li, Wentao, Hanson, Christian, Wu, James G., Li, Xian, Massaeli, Hamid, Zhang, Shetuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057800/
https://ncbi.nlm.nih.gov/pubmed/21177251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198408
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