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Interaction between the Cardiac Rapidly (I(Kr)) and Slowly (I(Ks)) Activating Delayed Rectifier Potassium Channels Revealed by Low K(+)-induced hERG Endocytic Degradation
Cardiac repolarization is controlled by the rapidly (I(Kr)) and slowly (I(Ks)) activating delayed rectifier potassium channels. The human ether-a-go-go-related gene (hERG) encodes I(Kr), whereas KCNQ1 and KCNE1 together encode I(Ks). Decreases in I(Kr) or I(Ks) cause long QT syndrome (LQTS), a cardi...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3186392/ https://ncbi.nlm.nih.gov/pubmed/21844197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253351 |
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