The Serum- and Glucocorticoid-inducible Kinases SGK1 and SGK3 Regulate hERG Channel Expression via Ubiquitin Ligase Nedd4-2 and GTPase Rab11

The hERG (human ether-a-go-go-related gene) encodes the α subunit of the rapidly activating delayed rectifier potassium channel (I(Kr)). Dysfunction of hERG channels due to mutations or certain medications causes long QT syndrome, which can lead to fatal ventricular arrhythmias or sudden death. Alth...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lamothe, Shawn M., Zhang, Shetuan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663528/
https://ncbi.nlm.nih.gov/pubmed/23589291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453670
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