Functional Regulation of the Epithelial Na(+) Channel by IκB Kinase-β Occurs via Phosphorylation of the Ubiquitin Ligase Nedd4-2

We have previously shown that IκB kinase-β (IKKβ) interacts with the epithelial Na(+) channel (ENaC) β-subunit and enhances ENaC activity by increasing its surface expression in Xenopus oocytes. Here, we show that the IKKβ-ENaC interaction is physiologically relevant in mouse polarized kidney cortic...

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Detalhes bibliográficos
Main Authors: Edinger, Robert S., Lebowitz, Jonathan, Li, Hui, Alzamora, Rodrigo, Wang, Huamin, Johnson, John P., Hallows, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610498/
https://ncbi.nlm.nih.gov/pubmed/18981174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807358200
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