AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells

The KCNQ1 K(+) channel plays a key role in the regulation of several physiological functions, including cardiac excitability, cardiovascular tone, and body electrolyte homeostasis. The metabolic sensor AMP-activated protein kinase (AMPK) has been shown to regulate a growing number of ion transport p...

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Detalhes bibliográficos
Principais autores: Alzamora, Rodrigo, Gong, Fan, Rondanino, Christine, Lee, Jeffrey K., Smolak, Christy, Pastor-Soler, Núria M., Hallows, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006313/
https://ncbi.nlm.nih.gov/pubmed/20861072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00423.2010
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