Regulation of Epithelial Na(+) Transport by Soluble Adenylyl Cyclase in Kidney Collecting Duct Cells

Alkalosis impairs the natriuretic response to diuretics, but the underlying mechanisms are unclear. The soluble adenylyl cyclase (sAC) is a chemosensor that mediates bicarbonate-dependent elevation of cAMP in intracellular microdomains. We hypothesized that sAC may be an important regulator of Na(+)...

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Autori principali: Hallows, Kenneth R., Wang, Huamin, Edinger, Robert S., Butterworth, Michael B., Oyster, Nicholas M., Li, Hui, Buck, Jochen, Levin, Lonny R., Johnson, John P., Pastor-Soler, Núria M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Membrane Transport, Structure, Function, and Biogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645828/
https://ncbi.nlm.nih.gov/pubmed/19126549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805501200
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