A Soluble Adenylyl Cyclase Form Targets to Axonemes and Rescues Beat Regulation in Soluble Adenylyl Cyclase Knockout Mice

Ciliary beating is important for effective mucociliary clearance. Soluble adenylyl cyclase (sAC) regulates ciliary beating, and a roughly 50-kD sAC variant is expressed in axonemes. Normal human bronchial epithelial (NHBE) cells express multiple sAC splice variants: full-length sAC; variants with ca...

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Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Autores principales: Chen, Xi, Baumlin, Nathalie, Buck, Jochen, Levin, Lonny R., Fregien, Nevis, Salathe, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2014
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291545/
https://ncbi.nlm.nih.gov/pubmed/24874272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0542OC
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