Soluble Adenylyl Cyclase Is Localized to Cilia and Contributes to Ciliary Beat Frequency Regulation via Production of cAMP

Ciliated airway epithelial cells are subject to sustained changes in intracellular CO(2)/HCO(3) (−) during exacerbations of airway diseases, but the role of CO(2)/HCO(3) (−)-sensitive soluble adenylyl cyclase (sAC) in ciliary beat regulation is unknown. We now show not only sAC expression in human a...

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Detalhes bibliográficos
Main Authors: Schmid, Andreas, Sutto, Zoltan, Nlend, Marie-Christine, Horvath, Gabor, Schmid, Nathalie, Buck, Jochen, Levin, Lonny R., Conner, Gregory E., Fregien, Nevis, Salathe, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154360/
https://ncbi.nlm.nih.gov/pubmed/17591988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709784
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