Decreased Soluble Adenylyl Cyclase Activity in Cystic Fibrosis Is Related to Defective Apical Bicarbonate Exchange and Affects Ciliary Beat Frequency Regulation

Human airway cilia contain soluble adenylyl cyclase (sAC) that produces cAMP upon HCO(3)(−)/CO(2) stimulation to increase ciliary beat frequency (CBF). Because apical HCO(3)(−) exchange depends on cystic fibrosis transmembrane conductance regulator (CFTR), malfunctioning CFTR might impair sAC-mediat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schmid, Andreas, Sutto, Zoltan, Schmid, Nathalie, Novak, Lisa, Ivonnet, Pedro, Horvath, Gabor, Conner, Gregory, Fregien, Nevis, Salathe, Matthias
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943327/
https://ncbi.nlm.nih.gov/pubmed/20639512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113621
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