Decreased Soluble Adenylyl Cyclase Activity in Cystic Fibrosis Is Related to Defective Apical Bicarbonate Exchange and Affects Ciliary Beat Frequency Regulation

Human airway cilia contain soluble adenylyl cyclase (sAC) that produces cAMP upon HCO(3)(−)/CO(2) stimulation to increase ciliary beat frequency (CBF). Because apical HCO(3)(−) exchange depends on cystic fibrosis transmembrane conductance regulator (CFTR), malfunctioning CFTR might impair sAC-mediat...

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Detalhes bibliográficos
Main Authors: Schmid, Andreas, Sutto, Zoltan, Schmid, Nathalie, Novak, Lisa, Ivonnet, Pedro, Horvath, Gabor, Conner, Gregory, Fregien, Nevis, Salathe, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943327/
https://ncbi.nlm.nih.gov/pubmed/20639512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113621
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