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Decreased Soluble Adenylyl Cyclase Activity in Cystic Fibrosis Is Related to Defective Apical Bicarbonate Exchange and Affects Ciliary Beat Frequency Regulation
Human airway cilia contain soluble adenylyl cyclase (sAC) that produces cAMP upon HCO(3)(−)/CO(2) stimulation to increase ciliary beat frequency (CBF). Because apical HCO(3)(−) exchange depends on cystic fibrosis transmembrane conductance regulator (CFTR), malfunctioning CFTR might impair sAC-mediat...
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| Huvudupphovsmän: | , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943327/ https://ncbi.nlm.nih.gov/pubmed/20639512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113621 |
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