Probing Ligand-binding Pockets of the Mevalonate Pathway Enzymes from Streptococcus pneumoniae

Diphosphomevalonate (Mev·pp) is the founding member of a new class of potential antibiotics targeting the Streptococcus pneumoniae mevalonate (Mev) pathway. We have synthesized a series of Mev·pp analogues designed to simultaneously block two steps in this pathway, through allosteric inhibition of m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lefurgy, Scott T., Rodriguez, Sofia B., Park, Chan Sun, Cahill, Sean, Silverman, Richard B., Leyh, Thomas S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898321/
https://ncbi.nlm.nih.gov/pubmed/20404339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098350
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