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Probing Ligand-binding Pockets of the Mevalonate Pathway Enzymes from Streptococcus pneumoniae
Diphosphomevalonate (Mev·pp) is the founding member of a new class of potential antibiotics targeting the Streptococcus pneumoniae mevalonate (Mev) pathway. We have synthesized a series of Mev·pp analogues designed to simultaneously block two steps in this pathway, through allosteric inhibition of m...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898321/ https://ncbi.nlm.nih.gov/pubmed/20404339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098350 |
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