Cathepsin H Is an Additional Convertase of Pro-granzyme B

The serine protease granzyme B (GrB) is the most potent proapoptotic cytotoxin of the granule exocytosis pathway of cytotoxic lymphocytes. GrB is synthesized as a zymogen (proGrB) and activated in cytotoxic granules by the lysosomal cysteine protease cathepsin C (CatC) which removes the N-terminal d...

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Bibliografiske detaljer
Main Authors: D'Angelo, Michael E., Bird, Phillip I., Peters, Christoph, Reinheckel, Thomas, Trapani, Joseph A., Sutton, Vivien R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898313/
https://ncbi.nlm.nih.gov/pubmed/20435891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094573
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