Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

The single transmembrane domain serine/threonine kinase activin receptor type IIB (ActRIIB) has been proposed to bind key regulators of skeletal muscle mass development, including the ligands GDF-8 (myostatin) and GDF-11 (BMP-11). Here we provide a detailed kinetic characterization of ActRIIB bindin...

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Main Authors: Sako, Dianne, Grinberg, Asya V., Liu, June, Davies, Monique V., Castonguay, Roselyne, Maniatis, Silas, Andreucci, Amy J., Pobre, Eileen G., Tomkinson, Kathleen N., Monnell, Travis E., Ucran, Jeffrey A., Martinez-Hackert, Erik, Pearsall, R. Scott, Underwood, Kathryn W., Seehra, Jasbir, Kumar, Ravindra
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898293/
https://ncbi.nlm.nih.gov/pubmed/20385559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114959
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