Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β superfamily, is an important regulator of normal blood vessel development as well as pathological tumor angiogenesis. As such, ALK1 is an important therapeutic target. Thus, several ALK1-directed agents...

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Detalhes bibliográficos
Main Authors: Townson, Sharon A., Martinez-Hackert, Erik, Greppi, Chloe, Lowden, Patricia, Sako, Dianne, Liu, June, Ucran, Jeffrey A., Liharska, Katia, Underwood, Kathryn W., Seehra, Jasbir, Kumar, Ravindra, Grinberg, Asya V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431715/
https://ncbi.nlm.nih.gov/pubmed/22718755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377960
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