Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

Endoglin (CD105), a transmembrane protein of the transforming growth factor β superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1). The soluble form of endoglin was suggested to contribute to the...

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Detalhes bibliográficos
Main Authors: Castonguay, Roselyne, Werner, Eric D., Matthews, Robert G., Presman, Eleonora, Mulivor, Aaron W., Solban, Nicolas, Sako, Dianne, Pearsall, R. Scott, Underwood, Kathryn W., Seehra, Jasbir, Kumar, Ravindra, Grinberg, Asya V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191044/
https://ncbi.nlm.nih.gov/pubmed/21737454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260133
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