Semliki Forest Virus-Induced Endoplasmic Reticulum Stress Accelerates Apoptotic Death of Mammalian Cells

The alphavirus Semliki Forest virus (SFV) and its derived vectors induce apoptosis in mammalian cells. Here, we show that apoptosis is associated with the loss of mitochondrial membrane potential followed by the activation of caspase-3, caspase-8, and caspase-9. Cell death can be partially suppresse...

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Main Authors: Barry, Gerald, Fragkoudis, Rennos, Ferguson, Mhairi C., Lulla, Aleksei, Merits, Andres, Kohl, Alain, Fazakerley, John K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898233/
https://ncbi.nlm.nih.gov/pubmed/20427528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02310-09
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