Differences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest Virus

The A7(74) strain of Semliki Forest virus (SFV; genus Alphavirus) is avirulent in adult mice, while the L10 strain is virulent in mice of all ages. It has been previously demonstrated that this phenotypic difference is associated with nonstructural protein 3 (nsP3). Consensus clones of L10 (designat...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Saul, Sirle, Ferguson, Mhairi, Cordonin, Colette, Fragkoudis, Rennos, Ool, Margit, Tamberg, Nele, Sherwood, Karen, Fazakerley, John K., Merits, Andres
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621116/
https://ncbi.nlm.nih.gov/pubmed/26311875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01186-15
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