Differences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest Virus

The A7(74) strain of Semliki Forest virus (SFV; genus Alphavirus) is avirulent in adult mice, while the L10 strain is virulent in mice of all ages. It has been previously demonstrated that this phenotypic difference is associated with nonstructural protein 3 (nsP3). Consensus clones of L10 (designat...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Saul, Sirle, Ferguson, Mhairi, Cordonin, Colette, Fragkoudis, Rennos, Ool, Margit, Tamberg, Nele, Sherwood, Karen, Fazakerley, John K., Merits, Andres
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621116/
https://ncbi.nlm.nih.gov/pubmed/26311875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01186-15
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