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Properly Folded Nonstructural Polyprotein Directs the Semliki Forest Virus Replication Complex to the Endosomal Compartment

The late RNA synthesis in alphavirus-infected cells, generating plus-strand RNAs, takes place on cytoplasmic vacuoles (CPVs), which are modified endosomes and lysosomes. The cytosolic surface of CPVs consists of regular membrane invaginations or spherules, which are the sites of RNA synthesis (P. Ku...

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Bibliografiske detaljer
Main Authors: Salonen, Anne, Vasiljeva, Lidia, Merits, Andres, Magden, Julia, Jokitalo, Eija, Kääriäinen, Leevi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140886/
https://ncbi.nlm.nih.gov/pubmed/12525603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.3.1691-1702.2003
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