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Silylene transfer to α-keto esters and application to the synthesis of γ-lactones

Disubstituted α-hydroxy acids have been synthesized by metal-catalyzed silylene transfer to α-keto esters. A range of substituents are tolerated in the transformation with the exception of branched groups at the vinylic position. The α-hydroxy acid products can be converted into γ-lactones using a v...

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Autori principali: Howard, Brett E., Woerpel, K. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898151/
https://ncbi.nlm.nih.gov/pubmed/20625460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2009.05.066
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