Substrate Selectivity and a Novel Role in Inhibitor Discrimination by Residue 237 in the KPC-2 β-Lactamase

β-Lactamase-mediated antibiotic resistance continues to challenge the contemporary treatment of serious bacterial infections. The KPC-2 β-lactamase, a rapidly emerging Gram-negative resistance determinant, hydrolyzes all commercially available β-lactams, including carbapenems and β-lactamase inhibit...

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Main Authors: Papp-Wallace, Krisztina M., Taracila, Magdalena, Hornick, John M., Hujer, Andrea M., Hujer, Kristine M., Distler, Anne M., Endimiani, Andrea, Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897288/
https://ncbi.nlm.nih.gov/pubmed/20421396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00197-10
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