Elucidating the role of Trp105 in the KPC-2 β-lactamase

The molecular basis of resistance to β-lactams and β-lactam-β-lactamase inhibitor combinations in the KPC family of class A enzymes is of extreme importance to the future design of effective β-lactam therapy. Recent crystal structures of KPC-2 and other class A β-lactamases suggest that Ambler posit...

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Bibliografiska uppgifter
Huvudupphovsmän: Papp-Wallace, Krisztina M, Taracila, Magdalena, Wallace, Christopher J, Hujer, Kristine M, Bethel, Christopher R, Hornick, John M, Bonomo, Robert A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975135/
https://ncbi.nlm.nih.gov/pubmed/20662006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.454
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