Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae

The imipenem-relebactam combination is in development as a potential treatment regimen for infections caused by Enterobacteriaceae possessing complex β-lactamase backgrounds. Relebactam is a β-lactamase inhibitor that possesses the diazabicyclooctane core, as in avibactam; however, the R1 side chain...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Papp-Wallace, Krisztina M., Barnes, Melissa D., Alsop, Jim, Taracila, Magdalena A., Bethel, Christopher R., Becka, Scott A., van Duin, David, Kreiswirth, Barry N., Kaye, Keith S., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971601/
https://ncbi.nlm.nih.gov/pubmed/29610205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00174-18
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