Exploring the Role of a Conserved Class A Residue in the Ω-Loop of KPC-2 β-Lactamase: A MECHANISM FOR CEFTAZIDIME HYDROLYSIS

Gram-negative bacteria harboring KPC-2, a class A β-lactamase, are resistant to all β-lactam antibiotics and pose a major public health threat. Arg-164 is a conserved residue in all class A β-lactamases and is located in the solvent-exposed Ω-loop of KPC-2. To probe the role of this amino acid in KP...

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Autores principales: Levitt, Peter S., Papp-Wallace, Krisztina M., Taracila, Magdalena A., Hujer, Andrea M., Winkler, Marisa L., Smith, Kerri M., Xu, Yan, Harris, Michael E., Bonomo, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442512/
https://ncbi.nlm.nih.gov/pubmed/22843686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.348540
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