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Non-Classical Anti-Factor VIII C2 Domain Antibodies Are Pathogenic in a Murine in vivo Bleeding Model

OBJECTIVE: The pathogenicity of anti-human fVIII monoclonal antibodies (MAbs) was tested in a murine bleeding model. METHODS: MAbs were injected into the tail veins of hemophilia A mice to a peak plasma concentration of 60 nM, followed by injection of human B domain-deleted factor VIII (fVIII) at 18...

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Bibliografiska uppgifter
Huvudupphovsmän: Meeks, Shannon L., Healey, John F., Parker, Ernest T., Barrow, Rachel T., Lollar, Pete
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897237/
https://ncbi.nlm.nih.gov/pubmed/19187078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03299.x
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