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RasGRP1 is required for human NK cell function

Cross-linking of NK activating receptors activates PLC-γ and subsequently induces DAG and Ca(2+) as second messengers of signal transduction. Previous studies reported that Ras guanyl nucleotide-releasing protein (RasGRP) 1, which is activated by DAG and Ca(2+), is crucial for T cell receptor-mediat...

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Detalhes bibliográficos
Main Authors: Lee, Suk Hyung, Yun, Sohyun, Kim, Mi Jeong, Lee, Jiwon, Chung, Jin Woong, Kim, Tae-Don, Yoon, Suk Ran, Greenberg, Philip D, Choi, Inpyo
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896689/
https://ncbi.nlm.nih.gov/pubmed/19933860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902012
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