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RasGRP1 is required for human NK cell function
Cross-linking of NK activating receptors activates PLC-γ and subsequently induces DAG and Ca(2+) as second messengers of signal transduction. Previous studies reported that Ras guanyl nucleotide-releasing protein (RasGRP) 1, which is activated by DAG and Ca(2+), is crucial for T cell receptor-mediat...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896689/ https://ncbi.nlm.nih.gov/pubmed/19933860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902012 |
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