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Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras
Galectin-3 (Gal-3) is a pleiotropic β-galactoside-binding protein expressed at relatively high levels in human neoplasms. Its carbohydrate recognition domain (CRD) contains a hydrophobic pocket that can accommodate the farnesyl moiety of K-Ras. Binding of K-Ras to Gal-3 stabilizes K-Ras in its activ...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3792567/ https://ncbi.nlm.nih.gov/pubmed/18413234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2008.03.009 |
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